Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 4/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.71 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.52 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | EEF2K | O00418 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL678403 | 0.83 | HMGCR (1.00) | HMGCRNR1I2GABBR2GABBR1PTGS1 | |
| SCHEMBL7139090 | 0.82 | HMGCR (0.71) | HMGCRNR1I2GABBR2GABBR1PTGS1 | |
| SCHEMBL7519377 | 0.80 | GABBR2 (0.61) | HMGCRNR1I2GABBR2GABBR1PTGS1 | |
| SCHEMBL12160467 | 0.77 | HMGCR (0.77) | HMGCRNR1I2GABBR2GABBR1PTGS1 | |
| SCHEMBL7134494 | 0.76 | HMGCR (0.85) | HMGCRNR1I2GABBR2GABBR1PTGS1 | |
| SCHEMBL7137096 | 0.76 | HMGCR (0.83) | HMGCRNR1I2GABBR2GABBR1PTGS1 | |
| SCHEMBL7083282 | 0.76 | HMGCR (0.83) | HMGCRNR1I2GABBR2GABBR1PTGS1 | |
| SCHEMBL9390686 | 0.73 | HMGCR (0.50) | HMGCRNR1I2GABBR2GABBR1PTGS1 | |
| SCHEMBL7521931 | 0.73 | HMGCR (0.80) | HMGCRNR1I2GABBR2GABBR1PTGS1 | |
| SCHEMBL17407580 | 0.73 | HMGCR (0.70) | HMGCRNR1I2GABBR2GABBR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0845991-B1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR SA (CH) | 2002-02-06 | — | — | EP | claimed |
| EP-0845991-A2 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR S.A. (CH) | 1998-06-10 | — | — | EP | claimed |
| WO-1997004785-A1 | USE OF PHENOL SUBSTITUTED DIPHOSPHONATES AS ANTINEOPLASTIC AGENTS | SYMPHAR S.A. (CH) | 1997-02-13 | — | — | WO | claimed |
| US-5128331-A | Gen-diphosphonates | SYMPHAR S.A. (CH) | 1992-07-07 | — | — | US | disclosed |
| US-5043330-A | Antiinflammatory and hypotensive agents; antihyperlipemia | SYMPHAR S.A. (CH) | 1991-08-27 | — | — | US | disclosed |