Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7519174 | 0.89 | HMGCR (0.47) | TYRHTTHPGDMAPK1NPSR1 | |
| SCHEMBL10790730 | 0.87 | TYR (0.61) | TYRHTTHPGDMAPK1NPSR1 | |
| SCHEMBL156399 | 0.82 | TYR (0.65) | TYRHTTHPGDMAPK1NPSR1 | |
| SCHEMBL28397980 | 0.81 | ALOX5 (0.61) | TYRHTTMEN1KMT2AMAPT | |
| SCHEMBL3382419 | 0.80 | TYR (0.63) | TYRHTTHPGDMAPK1NPSR1 | |
| SCHEMBL7521666 | 0.80 | TYR (0.44) | TYRHTTHPGDMAPK1NPSR1 | |
| SCHEMBL15868714 | 0.79 | ALOX5 (0.63) | TYRHTTMEN1KMT2AMAPT | |
| SCHEMBL15868713 | 0.79 | ALOX5 (0.63) | TYRHTTMEN1KMT2AMAPT | |
| SCHEMBL27313511 | 0.78 | BACE1 (0.46) | TYRHTTHPGDMAPK1NPSR1 | |
| SCHEMBL5678465 | 0.78 | TYR (0.59) | TYRHTTHPGDMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |