SCHEMBL7524145

SCHEMBL7524145

CC(c1cnc(=O)[nH]c1)c1cn(CCCC(=O)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)c(SCc2ccc(F)cc2)nc1=O

nearest known ligand 0.65

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 20/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7593767 0.91 PLA2G7 (0.63) PLA2G7
SCHEMBL7532480 0.89 PLA2G7 (0.60) PLA2G7
SCHEMBL7534683 0.85 PLA2G7 (0.64) PLA2G7
SCHEMBL7521954 0.82 PLA2G7 (0.58) PLA2G7
SCHEMBL7524150 0.79 PLA2G7 (1.00) PLA2G7
SCHEMBL7527491 0.78 PLA2G7 (1.00) PLA2G7
SCHEMBL7524828 0.78 PLA2G7 (0.64) PLA2G7
SCHEMBL7008207 0.78 PLA2G7 (0.56) PLA2G7
SCHEMBL7593775 0.76 PLA2G7 (1.00) PLA2G7
SCHEMBL7532481 0.74 PLA2G7 (0.84) PLA2G7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1173424-A1 PYRIMIDINE COMPOUNDS SMITHKLINE BEECHAM PLC (GB) 2002-01-23 EP disclosed
WO-2000066566-A1 PYRIMIDINE COMPOUNDS SMITHKLINE BEECHAM PLC (GB) 2000-11-09 WO disclosed