Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 16/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 10/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.35 |
| ▸ | HTR3B | O95264 | 3/20 | 0.35 |
| ▸ | HTR3A | P46098 | 3/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062954 | 0.88 | CHRNA7 (0.46) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7528052 | 0.80 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7061098 | 0.80 | CHRNA7 (0.68) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7061806 | 0.75 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL7063268 | 0.74 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL7162486 | 0.73 | CHRNA7 (0.36) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7649446 | 0.73 | CHRNA7 (0.46) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7059413 | 0.73 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3A | |
| SCHEMBL7155490 | 0.73 | CHRNA7 (0.40) | CHRNA7CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7061147 | 0.72 | CHRNA7 (0.40) | CHRNA7CHRNB2CHRNA4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002015662-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | claimed |