Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10726836 | 0.75 | APP (0.35) | TSHRALDH1A1NOTUMESR1ESR2 | |
| SCHEMBL9632223 | 0.72 | ESR1 (0.39) | TSHRALDH1A1KDM4ETRPA1NOTUM | |
| SCHEMBL936542 | 0.71 | ESR1 (0.32) | ALDH1A1ESR1ESR2APP | |
| SCHEMBL7162215 | 0.71 | ESR1 (0.32) | ALDH1A1ESR1ESR2APP | |
| SCHEMBL29572997 | 0.67 | TSHR (0.33) | TSHRALDH1A1KDM4EESR1ESR2 | |
| SCHEMBL8764198 | 0.67 | TSHR (0.33) | TSHRALDH1A1KDM4EESR1ESR2 | |
| SCHEMBL1240640 | 0.67 | MAPK1 (0.34) | TSHRALDH1A1KDM4EESR1ESR2 | |
| SCHEMBL22449340 | 0.67 | ALDH1A1 (0.30) | ALDH1A1ESR1ESR2 | |
| SCHEMBL5607685 | 0.67 | ESR1 (0.44) | TSHRALDH1A1ESR1ESR2CYP1A2 | |
| SCHEMBL24625721 | 0.65 | ALDH1A1 (0.50) | TSHRALDH1A1KDM4ECYP1A2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157143-A | DIASTEREOSELECTIVE PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PEPTIDE DERIVATIVES | ZAMBON GROUP S.P.A. (IT) | 1992-10-20 | — | — | US | claimed |
| EP-0341462-B1 | DIASTEREOSELECTIVE PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PEPTIDE DERIVATIVES | ZAMBON GROUP S.p.A. (IT) | 1992-09-09 | — | — | EP | claimed |
| EP-0341462-A1 | Diastereoselective process for the preparation of intermediates useful for the synthesis of peptide derivatives | ZAMBON GROUP S.p.A. (IT) | 1989-11-15 | — | — | EP | claimed |
| EP-0983249-B1 | PROCESSES AND INTERMEDIATES FOR PREPARING SUBSTITUTED INDAZOLE DERIVATIVES | PFIZER PROD INC (US) | 2002-03-13 | — | — | EP | disclosed |
| EP-0983249-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING SUBSTITUTED INDAZOLE DERIVATIVES | Pfizer Products Inc. (US) | 2000-03-08 | — | — | EP | disclosed |
| US-6011159-A | Processes and intermediates for preparing substituted indazole derivatives | PFIZER INC (US) | 2000-01-04 | — | — | US | disclosed |
| CN-1042336-C | Preparation of trialkylsilyl nitrile | HULS AMERICA INC (US) | 1999-03-03 | — | — | CN | disclosed |
| WO-1998050367-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING SUBSTITUTED INDAZOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-11-12 | — | — | WO | disclosed |
| EP-0349195-B1 | Direct synthesis by cationic polymerization of nitrogen-containing polymers | EXXON CHEMICAL PATENTS INC (US) | 1997-05-21 | — | — | EP | disclosed |
| US-5629394-A | ENDCAPPING ADDITION POLYMERS WITH NITROGEN FUNCTIONAL GROUPS WHICH CAN BE FURTHER DERIVATIZED | EXXON CHEMICAL PATENTS INC (US) | 1997-05-13 | — | — | US | disclosed |
| US-5444135-A | Polymerization and functionalization with nitrogen-containing functional groups occur simultaneously | EXXON CHEMICAL PATENTS INC. (US) | 1995-08-22 | — | — | US | disclosed |
| US-5336745-A | Terminally-substituted polymeric compositions from cationically polymerizable monomers and initiators | EXXON CHEMICAL PATENTS INC. (US) | 1994-08-09 | — | — | US | disclosed |
| US-5157143-A | DIASTEREOSELECTIVE PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PEPTIDE DERIVATIVES | ZAMBON GROUP S.P.A. (IT) | 1992-10-20 | — | — | US | disclosed |
| EP-0341462-B1 | DIASTEREOSELECTIVE PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PEPTIDE DERIVATIVES | ZAMBON GROUP S.p.A. (IT) | 1992-09-09 | — | — | EP | disclosed |
| US-5032653-A | Catalysts | EXXON CHEMICAL PATENTS, INC. (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0349195-A2 | Direct synthesis by cationic polymerization of nitrogen-containing polymers | EXXON CHEMICAL PATENTS INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| EP-0341462-A1 | Diastereoselective process for the preparation of intermediates useful for the synthesis of peptide derivatives | ZAMBON GROUP S.p.A. (IT) | 1989-11-15 | — | — | EP | disclosed |