SCHEMBL7524734

SCHEMBL7524734

O=C(O)CC(C=C(F)F)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.45
SUCNR1 Q9BXA5 1/20 0.41
ITGB3 P05106 2/20 0.40
ITGAV P06756 2/20 0.40
ALDH1A1 P00352 1/20 0.40
EPHX1 P07099 1/20 0.40
KMT2A Q03164 1/20 0.40
EPHX2 P34913 1/20 0.40
MRGPRX4 Q96LA9 1/20 0.39
AKR1C2 P52895 1/20 0.39
AKR1C1 Q04828 1/20 0.39
AURKA O14965 1/20 0.39
TPX2 Q9ULW0 1/20 0.39
MMP12 P39900 1/20 0.39
CTSA P10619 1/20 0.38
GRIK1 P39086 1/20 0.38
GRIK2 Q13002 1/20 0.38
PPARD Q03181 1/20 0.38
MAOB P27338 1/20 0.38
AOC3 Q16853 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29178245 0.79 FNTA (0.47) FFAR1SUCNR1ALDH1A1EPHX1KMT2A
SCHEMBL7523155 0.77 FFAR1 (0.44) FFAR1ALDH1A1KMT2ACTSA
SCHEMBL12836583 0.76 FFAR1 (0.53) FFAR1ALDH1A1EPHX1EPHX2
SCHEMBL12895102 0.76 FFAR1 (0.53) FFAR1ALDH1A1EPHX1EPHX2
SCHEMBL5371011 0.76 EPHX1 (0.46) SUCNR1ITGB3ITGAVALDH1A1EPHX1
SCHEMBL23340741 0.76 EPHX2 (0.44) SUCNR1ITGB3ITGAVALDH1A1EPHX1
SCHEMBL7235148 0.76 EPHX1 (0.46) SUCNR1ITGB3ITGAVALDH1A1EPHX1
SCHEMBL30219841 0.72 POLB (0.43) SUCNR1ITGB3ITGAVALDH1A1EPHX1
SCHEMBL15646890 0.70 EPHX2 (0.50) ALDH1A1EPHX1KMT2AEPHX2AKR1C2
SCHEMBL2946249 0.69 MMP9 (0.54) FFAR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1181267-A1 HALOGEN COMPOUNDS Bayer Aktiengesellschaft (DE) 2002-02-27 EP disclosed
WO-2000071500-A1 HALOGEN COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 2000-11-30 WO disclosed