SCHEMBL7524810

SCHEMBL7524810

CCN(CC)c1ccc(N2CCN(CC(=O)[C@H]3C(C)C[C@H]4[C@@H]5CCC6=CC(=O)C=C[C@]6(C)C5=CC[C@]34C)CC2)nc1N(CC)CC

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.71
PGR P06401 2/20 0.71
AR P10275 2/20 0.71
EGFR P00533 1/20 0.71
LCK P06239 1/20 0.71
FYN P06241 1/20 0.71
ADRB2 P07550 1/20 0.71
CHRM2 P08172 1/20 0.71
ADRA2A P08913 1/20 0.71
ADORA3 P0DMS8 1/20 0.71
ADRA2C P18825 1/20 0.71
DRD1 P21728 1/20 0.71
PTGS1 P23219 1/20 0.71
HRH2 P25021 1/20 0.71
MAPK3 P27361 1/20 0.71
PDE4A P27815 1/20 0.71
HTR2A P28223 1/20 0.71
HTR2C P28335 1/20 0.71
DRD3 P35462 1/20 0.71
HTR2B P41595 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7524804 1.00 KCNH2 (0.71) KCNH2PGRAREGFRLCK
SCHEMBL8745521 0.89 KCNH2 (0.66) KCNH2PGRAREGFRLCK
SCHEMBL8745497 0.89 KCNH2 (0.66) KCNH2PGRAREGFRLCK
SCHEMBL9200483 0.89 KCNH2 (0.72) KCNH2PGRAREGFRLCK
SCHEMBL9200472 0.89 KCNH2 (0.72) KCNH2PGRAREGFRLCK
Hydrochloric Acid SCHEMBL31690230 0.88 KCNH2 (0.66) KCNH2PGRAREGFRLCK
Hydrochloric Acid SCHEMBL5824121 0.88 KCNH2 (0.66) KCNH2PGRAREGFRLCK
Hydrochloric Acid SCHEMBL9210207 0.88 KCNH2 (0.71) KCNH2PGRAREGFRLCK
SCHEMBL9226769 0.88 KCNH2 (0.69) KCNH2PGRAREGFRLCK
SCHEMBL9226772 0.88 KCNH2 (0.69) KCNH2PGRAREGFRLCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023154647-A1 COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF DISEASES UTILIZING TIRILAZAD SALTS PRENDERGAST PATRICK T (IE) 2023-08-17 WO claimed
EP-0792153-B1 COMPOSITIONS CONTAINING LAZAROIDS AND THEIR USE FOR PREVENTING ADHESIONS UNIV SOUTHERN CALIFORNIA (US) 2002-03-27 EP claimed
EP-0792153-A1 COMPOSITIONS CONTAINING LAZAROIDS AND THEIR USE FOR PREVENTING ADHESIONS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1997-09-03 EP claimed
US-5614515-A PREVENTING TISSUE ADHESION AFTER SURGERY UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1997-03-25 US claimed
US-5538721-A LIGHTLY CROSSLINKED CARBOXY POLYMER INSITE VISION INCORPORATED (US) 1996-07-23 US claimed
WO-1996015795-A1 COMPOSITIONS CONTAINING LAZAROIDS AND THEIR USE FOR PREVENTING ADHESIONS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1996-05-30 WO claimed
EP-0238545-B1 C20 THROUGH C26 AMINO STEROIDS UPJOHN CO (US) 1995-11-15 EP claimed
EP-0263213-B1 C20 Through C26 amino steroids UPJOHN CO (US) 1995-09-06 EP claimed
US-5380841-A Steroids as antiinflammatory agents THE UPJOHN COMPANY (US) 1995-01-10 US claimed
US-5332582-A Lightly crosslinked carboxy-containing polymers INSITE VISION INCORPORATED (US) 1994-07-26 US claimed
US-5175281-A Antiulcer, antiinflammatory, antiischemic, antiallergen, antisecretory, wound healing agents; cardiovascular disorders THE UPJOHN COMPANY (US) 1992-12-29 US claimed
WO-2023154647-A1 COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF DISEASES UTILIZING TIRILAZAD SALTS PRENDERGAST PATRICK T (IE) 2023-08-17 WO disclosed
US-6372245-B1 Plasticized bioerodible controlled delivery system INSITE VISION INCORPORATED 2002-04-16 US disclosed
EP-0676952-B1 BIOERODIBLE CONTROLLED DELIVERY SYSTEM INSITE VISION INC (US) 2000-07-12 EP disclosed
EP-0676953-B1 PLASTICIZED BIOERODIBLE CONTROLLED DELIVERY SYSTEM INSITE VISION INC (US) 1999-05-06 EP disclosed
US-5256408-A Aminosteroids for ophthalmic use INSITE VISION INCORPORATED (US) 1993-10-26 US disclosed
US-5252319-A Aminosteroids for ophthalmic use INSITE VISION INCORPORATED (US) 1993-10-12 US disclosed
US-5209926-A Aminosteroids for ophthalmic use INSITE VISION INCORPORATED (US) 1993-05-11 US disclosed
US-5124154-A AMINOSTEROIDS FOR OPHTHALMIC USE INSITE VISION INCORPORATED (US) 1992-06-23 US disclosed
WO-1991019482-A1 AMINOSTEROIDS FOR OPHTHALMIC USE INSITE VISION INCORPORATED (US) 1991-12-26 WO disclosed