Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.60 |
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7525284 | 1.00 | ADORA3 (0.60) | ADORA3ADORA1NT5EADORA2ADNPH1 | |
| SCHEMBL7531045 | 0.92 | ADORA3 (0.61) | ADORA3ADORA1NT5EADORA2ADNPH1 | |
| SCHEMBL7531052 | 0.92 | ADORA3 (0.61) | ADORA3ADORA1NT5EADORA2ADNPH1 | |
| SCHEMBL7526426 | 0.89 | ADORA3 (0.59) | ADORA3ADORA1NT5EDNPH1LMNA | |
| SCHEMBL7526418 | 0.89 | ADORA3 (0.59) | ADORA3ADORA1NT5EDNPH1LMNA | |
| SCHEMBL7527254 | 0.89 | ADORA3 (0.66) | ADORA3ADORA1NT5EADORA2A | |
| SCHEMBL7527246 | 0.89 | ADORA3 (0.66) | ADORA3ADORA1NT5EADORA2A | |
| SCHEMBL7531978 | 0.89 | ADORA1 (0.54) | ADORA3ADORA1NT5EADORA2ADNPH1 | |
| SCHEMBL7531983 | 0.89 | ADORA1 (0.54) | ADORA3ADORA1NT5EADORA2ADNPH1 | |
| SCHEMBL8375132 | 0.89 | ADORA3 (0.53) | ADORA3ADORA1NT5EDNPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901499-B1 | ADENOSINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-04-10 | — | — | EP | claimed |
| US-5998388-A | N6-PHENYL-SUBSTITUTED | GLAXO WELLCOME INC. (US) | 1999-12-07 | — | — | US | claimed |
| EP-0901499-B1 | ADENOSINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-04-10 | — | — | EP | disclosed |
| US-5998388-A | N6-PHENYL-SUBSTITUTED | GLAXO WELLCOME INC. (US) | 1999-12-07 | — | — | US | disclosed |