Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 12/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.71 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.49 |
| ▸ | EBP | Q15125 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966174 | 0.94 | ESR1 (0.80) | ESR1ESR2HRH3PGRCHRM2 | |
| SCHEMBL7524349 | 0.90 | ESR1 (0.88) | ESR1ESR2HRH3 | |
| SCHEMBL8610437 | 0.89 | ESR1 (0.86) | ESR1ESR2HRH3 | |
| SCHEMBL8966218 | 0.87 | ESR1 (0.76) | ESR1ESR2HRH3 | |
| SCHEMBL7525280 | 0.86 | ESR1 (0.69) | ESR1ESR2 | |
| SCHEMBL7528598 | 0.85 | ESR1 (0.67) | ESR1ESR2HRH3PGRCHRM2 | |
| SCHEMBL8966242 | 0.84 | ESR1 (0.68) | ESR1ESR2HRH3EBPSIGMAR1 | |
| SCHEMBL8965793 | 0.84 | ESR1 (0.68) | ESR1ESR2HRH3EBPSIGMAR1 | |
| SCHEMBL8966205 | 0.83 | ESR1 (1.00) | ESR1ESR2HRH3 | |
| SCHEMBL7527242 | 0.83 | ESR1 (0.66) | ESR1ESR2HRH3EBPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832882-B1 | Naphthofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0832882-A2 | Naphthofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |