Sugi Predict

Sugi Predict / Compounds / SCHEMBL7526072

SCHEMBL7526072

SCHEMBL7526072

CCOC(=O)C(C)(C)Oc1ccc(CNC(=O)c2sc(-c3cc(C(F)(F)F)ccn3)nc2C)cc1.CCOC(=O)C(C)(C)Oc1ccc(CNC(=O)c2sc(-c3ccc(C(F)(F)F)cc3)nc2C)cc1OC

nearest known ligand 0.61

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PPARA Q07869 20/20 0.61
▸ PPARD Q03181 8/20 0.61
▸ PPARG P37231 5/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7466720 0.93 PPARA (0.73) PPARAPPARDPPARG
SCHEMBL6582991 0.90 PPARA (0.62) PPARAPPARDPPARG
SCHEMBL6582598 0.90 PPARA (0.63) PPARAPPARDPPARG
SCHEMBL5185069 0.86 PPARA (0.82) PPARAPPARDPPARG
SCHEMBL6583596 0.83 PPARA (0.64) PPARAPPARDPPARG
SCHEMBL6582510 0.82 PPARA (0.75) PPARAPPARDPPARG
SCHEMBL6582790 0.81 PPARA (0.76) PPARAPPARDPPARG
SCHEMBL6583337 0.81 PPARA (0.80) PPARAPPARDPPARG
SCHEMBL6583647 0.81 PPARA (0.80) PPARAPPARDPPARG
SCHEMBL6581261 0.80 PPARA (0.81) PPARAPPARDPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1244642-A1 SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2002-10-02 — — EP claimed
WO-2001040207-A1 SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2001-06-07 — — WO claimed
EP-1244642-A1 SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2002-10-02 — — EP disclosed
WO-2001040207-A1 SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2001-06-07 — — WO disclosed