Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 19/20 | 0.64 |
| ▸ | PPARG | P37231 | 7/20 | 0.64 |
| ▸ | PPARD | Q03181 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582598 | 0.93 | PPARA (0.63) | PPARAPPARGPPARDNPC1ALDH1A1 | |
| SCHEMBL6580900 | 0.91 | PPARA (0.77) | PPARAPPARGPPARD | |
| SCHEMBL6584688 | 0.88 | PPARA (0.53) | PPARAPPARGPPARD | |
| SCHEMBL5185069 | 0.88 | PPARA (0.82) | PPARAPPARGPPARD | |
| SCHEMBL4678194 | 0.86 | PPARD (0.52) | PPARAPPARGPPARDNPC1ALDH1A1 | |
| SCHEMBL7560728 | 0.85 | PPARA (0.64) | PPARAPPARGPPARD | |
| SCHEMBL1549997 | 0.83 | PPARG (0.50) | PPARAPPARGPPARD | |
| SCHEMBL6582790 | 0.83 | PPARA (0.76) | PPARAPPARGPPARD | |
| SCHEMBL7526072 | 0.83 | PPARA (0.61) | PPARAPPARGPPARD | |
| SCHEMBL6582740 | 0.81 | PPARA (0.82) | PPARAPPARGPPARDNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244642-B1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-28 | — | — | EP | claimed |
| US-6518290-B1 | Compounds that activate or otherwise interact with one or more of the PPARs have been implicated in the regulation of triglyceride and cholesterol levels in animal models | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | claimed |
| EP-1244642-B1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-28 | — | — | EP | disclosed |
| US-6518290-B1 | Compounds that activate or otherwise interact with one or more of the PPARs have been implicated in the regulation of triglyceride and cholesterol levels in animal models | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |
| EP-1244642-A1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040207-A1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2001-06-07 | — | — | WO | disclosed |