SCHEMBL7526353

SCHEMBL7526353

C(#Cc1ccc(-c2ccccc2-c2ccc(C#Cc3ccccc3)cc2)cc1)c1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 1/20 0.63
MAPT P10636 2/20 0.54
CYP1A2 P05177 3/20 0.50
CYP1A1 P04798 1/20 0.50
CYP1B1 Q16678 1/20 0.50
KCNH2 Q12809 2/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA9 Q16790 1/20 0.45
GRM5 P41594 3/20 0.44
FFAR1 O14842 5/20 0.43
CYP3A4 P08684 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.43
NPC1 O15118 1/20 0.43
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7526751 0.86 GRM5 (0.56) APPMAPTCYP1A2CYP1A1CYP1B1
SCHEMBL2306498 0.86 APP (0.52) APPMAPTCYP1A2CYP1A1CYP1B1
SCHEMBL5949303 0.86 APP (0.75) APPMAPTCYP1A2CYP1A1CYP1B1
SCHEMBL7997661 0.84 GRM5 (0.55) APPMAPTCYP1A2CYP1A1CYP1B1
SCHEMBL5886608 0.83 APP (0.71) APPMAPTCYP1A2CYP1A1CYP1B1
Diphenylacetylene SCHEMBL27557446 0.83 APP (0.80) APPMAPTCYP1A2KCNH2CA12
SCHEMBL2114741 0.83 APP (0.92) APPMAPTCYP1A2CYP1A1CYP1B1
SCHEMBL5872097 0.83 APP (0.48) APPMAPTCYP1A2CYP1A1CYP1B1
Methane SCHEMBL28739770 0.81 APP (0.67) APPMAPTCYP1A2CYP1A1CYP1B1
SCHEMBL8491741 0.81 FFAR1 (0.49) APPMAPTCYP1A2CYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889920-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1999-01-13 EP claimed
WO-1998011149-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1998-03-19 WO claimed
EP-0889920-B1 POLYPHENYLENE OLIGOMERS AND POLYMERS DOW CHEMICAL CO (US) 2002-02-13 EP disclosed
US-6288188-B1 ACETYLENIC POLYMERS; INTEGRATED CIRCUITS, DIELECTRICS, MICROELECTRONICS THE DOW CHEMICAL COMPANY 2001-09-11 US disclosed
US-5965679-A BASED A BISCYCLOPENTADIENONE AND AN AROMATIC DIACETYLENE; CURING; LOW DIELECTRIC; INTEGRATED CIRCUITS; MICROELECTRONICS; PRINTED CIRCUITS THE DOW CHEMICAL COMPANY (US) 1999-10-12 US disclosed
EP-0889920-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1999-01-13 EP disclosed
WO-1998011149-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1998-03-19 WO disclosed