SCHEMBL7526751

SCHEMBL7526751

C(#Cc1ccc(-c2ccc(C#Cc3ccccc3)cc2-c2ccc(C#Cc3ccccc3)cc2)cc1)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 9/20 0.56
APP P05067 1/20 0.52
MAPT P10636 1/20 0.46
CYP1A1 P04798 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP1B1 Q16678 1/20 0.43
HNF4A P41235 1/20 0.43
ASIC3 Q9UHC3 2/20 0.42
CA12 O43570 2/20 0.40
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA9 Q16790 2/20 0.40
KCNH2 Q12809 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7997661 0.98 GRM5 (0.55) GRM5APPMAPTCYP1A1CYP1A2
SCHEMBL7526353 0.86 APP (0.63) GRM5APPMAPTCYP1A1CYP1A2
SCHEMBL5949303 0.78 APP (0.75) GRM5APPMAPTCYP1A1CYP1A2
SCHEMBL8909968 0.77 GRM5 (0.65) GRM5APPMAPTHNF4ACA12
SCHEMBL2295150 0.77 APP (0.63) GRM5APPMAPTCYP1A1CYP1A2
SCHEMBL5886608 0.76 APP (0.71) GRM5APPMAPTCYP1A1CYP1A2
SCHEMBL3797658 0.76 CYP1A1 (0.56) GRM5APPMAPTCYP1A1CYP1A2
SCHEMBL2114741 0.75 APP (0.92) GRM5APPMAPTCYP1A1CYP1A2
Diphenylacetylene SCHEMBL27628902 0.75 APP (0.92) GRM5APPMAPTCYP1A2HNF4A
SCHEMBL31741945 0.75 PTGDR2 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0889920-B1 POLYPHENYLENE OLIGOMERS AND POLYMERS DOW CHEMICAL CO (US) 2002-02-13 EP claimed
US-5965679-A BASED A BISCYCLOPENTADIENONE AND AN AROMATIC DIACETYLENE; CURING; LOW DIELECTRIC; INTEGRATED CIRCUITS; MICROELECTRONICS; PRINTED CIRCUITS THE DOW CHEMICAL COMPANY (US) 1999-10-12 US claimed
EP-0889920-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1999-01-13 EP claimed
WO-1998011149-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1998-03-19 WO claimed
EP-0889920-B1 POLYPHENYLENE OLIGOMERS AND POLYMERS DOW CHEMICAL CO (US) 2002-02-13 EP disclosed
US-6288188-B1 ACETYLENIC POLYMERS; INTEGRATED CIRCUITS, DIELECTRICS, MICROELECTRONICS THE DOW CHEMICAL COMPANY 2001-09-11 US disclosed
US-5965679-A BASED A BISCYCLOPENTADIENONE AND AN AROMATIC DIACETYLENE; CURING; LOW DIELECTRIC; INTEGRATED CIRCUITS; MICROELECTRONICS; PRINTED CIRCUITS THE DOW CHEMICAL COMPANY (US) 1999-10-12 US disclosed
EP-0889920-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1999-01-13 EP disclosed
WO-1998011149-A1 POLYPHENYLENE OLIGOMERS AND POLYMERS THE DOW CHEMICAL COMPANY (US) 1998-03-19 WO disclosed