Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL10637065 | 1.00 | FFAR3 (0.58) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL1238242 | 1.00 | FFAR3 (0.58) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL6238375 | 1.00 | FFAR3 (0.58) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL21806304 | 1.00 | FFAR3 (0.58) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL300016 | 1.00 | FFAR3 (0.58) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL10630506 | 1.00 | FFAR3 (0.58) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL1695866 | 0.96 | FFAR3 (0.54) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL4894483 | 0.96 | FFAR3 (0.54) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL27855554 | 0.96 | FFAR3 (0.54) | FFAR3LCKFYNTP53SLC7A5 | |
| Acetic Acid SCHEMBL11579190 | 0.93 | FFAR3 (0.50) | FFAR3LCKFYNTP53SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194126-A1 | DRY POWDER COMPOSITIONS | Quadrant Healthcare (UK) Limited (GB) | 2002-04-10 | — | — | EP | claimed |
| WO-2001003673-A1 | DRY POWDER COMPOSITIONS | QUADRANT HEALTHCARE (UK) LIMITED (GB) | 2001-01-18 | — | — | WO | claimed |
| EP-1194126-A1 | DRY POWDER COMPOSITIONS | Quadrant Healthcare (UK) Limited (GB) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001003673-A1 | DRY POWDER COMPOSITIONS | QUADRANT HEALTHCARE (UK) LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |