Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23158588 | 0.91 | MAPT (0.70) | MAPTMAPK1USP2HRH3CYP1A1 | |
| SCHEMBL23158589 | 0.91 | MAPT (0.70) | MAPTMAPK1USP2HRH3CYP1A1 | |
| SCHEMBL26260179 | 0.91 | MAPT (0.70) | MAPTMAPK1USP2HRH3CYP1A1 | |
| SCHEMBL23158600 | 0.91 | MAPT (0.70) | MAPTMAPK1USP2HRH3CYP1A1 | |
| SCHEMBL12379451 | 0.89 | USP2 (0.80) | MAPTMAPK1USP2HRH3CYP1A1 | |
| SCHEMBL2290207 | 0.89 | USP2 (0.80) | MAPTMAPK1USP2HRH3CYP1A1 | |
| SCHEMBL7518219 | 0.89 | USP2 (0.80) | MAPTMAPK1USP2HRH3CYP1A1 | |
| SCHEMBL7521943 | 0.89 | MAPT (0.67) | MAPTMAPK1USP2HRH3CYP1A1 | |
| SCHEMBL7521946 | 0.89 | MAPT (0.67) | MAPTMAPK1USP2HRH3CYP1A1 | |
| SCHEMBL7530626 | 0.87 | MAPT (0.65) | MAPTMAPK1USP2HRH3CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476012-B2 | FOR THERAPY OF SYMPTOMOLOGY ASSOCIATED WITH MENOPAUSE | YALE UNIVERSITY | 2002-11-05 | — | — | US | disclosed |
| US-20020143002-A1 | Estradiol-16alpha-carboxylic acid esters as locally active estrogens | YALE UNIVERSITY | 2002-10-03 | — | — | US | disclosed |
| WO-2002058634-A2 | ESTRADIOL-16α-CARBOXYLIC ACID ESTERS AS LOCALLY ACTIVE ESTROGENS | YALE UNIVERSITY (US) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020143002-A1 | Estradiol-16alpha-carboxylic acid esters as locally active estrogens | ESR1, ESR2, GPER1 | MAPT 4839/4885MAPK1 2798/4885USP2 1185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.