Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.59 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.59 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.59 |
| ▸ | STS | P08842 | 3/20 | 0.59 |
| ▸ | RORC | P51449 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.54 |
| ▸ | SHBG | P04278 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2290207 | 1.00 | USP2 (0.80) | USP2MAPTMAPK1HRH3CYP1A1 | |
| SCHEMBL12379451 | 1.00 | USP2 (0.80) | USP2MAPTMAPK1HRH3CYP1A1 | |
| SCHEMBL1979069 | 0.92 | USP2 (0.76) | USP2MAPTMAPK1HRH3CYP1A1 | |
| SCHEMBL1979067 | 0.92 | USP2 (0.76) | USP2MAPTMAPK1HRH3CYP1A1 | |
| SCHEMBL12379442 | 0.92 | USP2 (0.76) | USP2MAPTMAPK1HRH3CYP1A1 | |
| SCHEMBL12379469 | 0.89 | USP2 (0.72) | USP2MAPTMAPK1HRH3CYP1A1 | |
| SCHEMBL2291026 | 0.89 | USP2 (0.72) | USP2MAPTMAPK1HRH3CYP1A1 | |
| SCHEMBL12379467 | 0.89 | USP2 (0.72) | USP2MAPTMAPK1HRH3CYP1A1 | |
| SCHEMBL7528658 | 0.89 | MAPT (0.69) | USP2MAPTMAPK1HRH3CYP1A1 | |
| SCHEMBL14360840 | 0.89 | MAPT (1.00) | USP2MAPTMAPK1HRH3CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476012-B2 | FOR THERAPY OF SYMPTOMOLOGY ASSOCIATED WITH MENOPAUSE | YALE UNIVERSITY | 2002-11-05 | — | — | US | disclosed |
| US-20020143002-A1 | Estradiol-16alpha-carboxylic acid esters as locally active estrogens | YALE UNIVERSITY | 2002-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020143002-A1 | Estradiol-16alpha-carboxylic acid esters as locally active estrogens | ESR1, ESR2, GPER1 | USP2 1185/4885MAPT 4839/4885MAPK1 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.