SCHEMBL7529022

SCHEMBL7529022

COC(=O)c1ccc(C=Cc2ccc(NC(=O)c3ccc(N(C)C(=O)c4ccc(C(=O)OC)cc4)cc3)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.60
ALDH1A1 P00352 4/20 0.60
MEN1 O00255 4/20 0.60
LMNA P02545 3/20 0.60
KDM4E B2RXH2 3/20 0.60
HSD17B10 Q99714 2/20 0.60
TSHR P16473 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
NPC1 O15118 5/20 0.55
RAB9A P51151 5/20 0.55
ATM Q13315 1/20 0.55
PTPN1 P18031 2/20 0.52
PSMD14 O00487 1/20 0.48
CACNA1B Q00975 1/20 0.48
APBA1 Q02410 1/20 0.48
HTT P42858 2/20 0.47
NOTUM Q6P988 1/20 0.47
TP53 P04637 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
MAPT P10636 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7529010 1.00 KMT2A (0.60) KMT2AALDH1A1MEN1LMNAKDM4E
SCHEMBL7646488 0.95 KMT2A (0.55) KMT2AALDH1A1MEN1LMNAKDM4E
SCHEMBL7526766 0.95 KMT2A (0.55) KMT2AALDH1A1MEN1LMNAKDM4E
SCHEMBL7646483 0.95 KMT2A (0.55) KMT2AALDH1A1MEN1LMNAKDM4E
SCHEMBL7533131 0.91 NOTUM (0.55) KMT2AALDH1A1MEN1LMNAKDM4E
SCHEMBL7533139 0.91 NOTUM (0.55) KMT2AALDH1A1MEN1LMNAKDM4E
SCHEMBL7646103 0.85 NOTUM (0.50) KMT2AALDH1A1MEN1LMNAKDM4E
SCHEMBL7646207 0.85 NOTUM (0.50) KMT2AALDH1A1MEN1LMNAKDM4E
SCHEMBL7646203 0.85 NOTUM (0.50) KMT2AALDH1A1MEN1LMNAKDM4E
SCHEMBL5722247 0.85 PTPN1 (0.64) KMT2AALDH1A1MEN1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers TELIK, INC. 2002-03-14 US claimed
US-6479548-B2 P-(BENZOYLAMINO)STILBENE DERIVATIVES TELIK, INC. 2002-11-12 US disclosed
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers TELIK, INC. 2002-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers SLC2A1, SLC2A8, SLC2A2 KMT2A 3788/4885ALDH1A1 1811/4885MEN1 2354/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.