Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7528378 | 0.99 | HPGD (0.37) | P4HBHPGDSMAD3EBPSIGMAR1 | |
| SCHEMBL7524279 | 0.90 | EBP (0.41) | P4HBHPGDSMAD3EBPSIGMAR1 | |
| SCHEMBL7529231 | 0.81 | EBP (0.57) | EBPSIGMAR1MAPTESR1 | |
| SCHEMBL3861283 | 0.80 | EBP (0.58) | EBPSIGMAR1ALDH1A1ESR1 | |
| SCHEMBL7529404 | 0.80 | ESR1 (0.45) | HPGDLMNATP53MEN1KMT2A | |
| SCHEMBL7532743 | 0.77 | ESR1 (0.43) | HPGDLMNATP53MEN1KMT2A | |
| SCHEMBL7529223 | 0.77 | EBP (0.44) | HPGDEBPSIGMAR1LMNATP53 | |
| SCHEMBL7528373 | 0.76 | EBP (0.44) | HPGDEBPSIGMAR1LMNATP53 | |
| SCHEMBL7529402 | 0.74 | EBP (0.41) | HPGDEBPSIGMAR1PKMLMNA | |
| SCHEMBL11481224 | 0.73 | ESR1 (0.54) | HPGDLMNAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832883-B1 | Tetrahydrobenzo(a)fluorene compounds and methods of use | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5821253-A | INHIBIT BONE LOSS OR RESORPTION, LOWER SERUM CHOLESTEROL LEVELS | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0832883-A1 | Tetrahydrobenzo(a)fluorene compounds and methods of use | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |