Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532743 | 0.95 | ESR1 (0.43) | ESR1ESR2ALDH1A1KDM4ELMNA | |
| SCHEMBL11481224 | 0.91 | ESR1 (0.54) | ESR1ESR2ALDH1A1KDM4ELMNA | |
| SCHEMBL8609912 | 0.90 | ESR1 (0.51) | ESR1ESR2ALDH1A1LMNAMAPT | |
| SCHEMBL7942835 | 0.85 | ALDH1A1 (0.46) | ESR1ESR2ALDH1A1KDM4ELMNA | |
| SCHEMBL4651132 | 0.84 | ESR1 (0.40) | ESR1ESR2ALDH1A1KDM4ELMNA | |
| SCHEMBL7946063 | 0.82 | ESR1 (0.49) | ESR1ESR2ALDH1A1KDM4ELMNA | |
| SCHEMBL7942846 | 0.81 | ESR1 (0.51) | ESR1ESR2ALDH1A1KDM4EGAA | |
| SCHEMBL4653144 | 0.81 | ACHE (0.39) | ESR1ESR2ALDH1A1KDM4ELMNA | |
| SCHEMBL7528378 | 0.80 | HPGD (0.37) | ESR1ALDH1A1LMNAMAPTMEN1 | |
| Trioxifene SCHEMBL4651963 | 0.80 | ESR1 (0.69) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832883-B1 | Tetrahydrobenzo(a)fluorene compounds and methods of use | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5821253-A | INHIBIT BONE LOSS OR RESORPTION, LOWER SERUM CHOLESTEROL LEVELS | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0832883-A1 | Tetrahydrobenzo(a)fluorene compounds and methods of use | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |