SCHEMBL7529565

SCHEMBL7529565

CCCSC(C(N)=O)c1cccc(C(=O)c2ccc(Cl)cc2)c1N

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.38
CHRNA7 P36544 1/20 0.36
MEN1 O00255 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36
MAPT P10636 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
ABCB11 O95342 1/20 0.34
LMNA P02545 1/20 0.34
PTGS1 P23219 1/20 0.34
ADORA1 P30542 1/20 0.34
PTGS2 P35354 1/20 0.34
MAPK14 Q16539 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1569351 0.90 GAA (0.40) MEN1KMT2AMAPTABCB11LMNA
SCHEMBL7522882 0.89 EPHX1 (0.38) ABCB11LMNAPTGS1ADORA1PTGS2
SCHEMBL11227083 0.79 NR4A1 (0.46) NR4A1MEN1RAB9AKMT2AMAPT
SCHEMBL9747730 0.77 NR4A1 (0.46) NR4A1CHRNA7MEN1RAB9AKMT2A
SCHEMBL10764202 0.76 NR4A1 (0.44) NR4A1CHRNA7MEN1RAB9AKMT2A
SCHEMBL10764203 0.73 NR4A1 (0.40) NR4A1
SCHEMBL9747726 0.73 NR4A1 (0.49) NR4A1MEN1RAB9AKMT2AMAPT
SCHEMBL1569324 0.73 MAPT (0.45) MEN1KMT2AMAPTABCB11LMNA
SCHEMBL30692375 0.73 MAPT (0.45) MEN1KMT2AMAPTABCB11LMNA
SCHEMBL16340488 0.72 MAPT (0.39) MEN1KMT2AMAPTABCB11LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0716600-B1 TOPICALLY ADMINISTRABLE COMPOSITIONS CONTAINING 3-BENZOYLPHENYLACETIC ACID DERIVATIVES FOR TREATMENT OF OPHTHALMIC INFLAMMATORY DISORDERS ALCON LAB INC (US) 2002-04-03 EP claimed
EP-0716600-A1 TOPICALLY ADMINISTRABLE COMPOSITIONS CONTAINING 3-BENZOYLPHENYLACETIC ACID DERIVATIVES FOR TREATMENT OF OPHTHALMIC INFLAMMATORY DISORDERS ALCON LABORATORIES, INC. (US) 1996-06-19 EP claimed
WO-1995033457-A1 TOPICALLY ADMINISTRABLE COMPOSITIONS CONTAINING 3-BENZOYLPHENYLACETIC ACID DERIVATIVES FOR TREATMENT OF OPHTHALMIC INFLAMMATORY DISORDERS ALCON LABORATORIES, INC. (US) 1995-12-14 WO claimed
US-5475034-A Adminstering 3-benzoylphenylacetamide derivatives ALCON LABORATORIES, INC. (US) 1995-12-12 US claimed
EP-0716600-B1 TOPICALLY ADMINISTRABLE COMPOSITIONS CONTAINING 3-BENZOYLPHENYLACETIC ACID DERIVATIVES FOR TREATMENT OF OPHTHALMIC INFLAMMATORY DISORDERS ALCON LAB INC (US) 2002-04-03 EP disclosed
EP-0716600-A1 TOPICALLY ADMINISTRABLE COMPOSITIONS CONTAINING 3-BENZOYLPHENYLACETIC ACID DERIVATIVES FOR TREATMENT OF OPHTHALMIC INFLAMMATORY DISORDERS ALCON LABORATORIES, INC. (US) 1996-06-19 EP disclosed
WO-1995033457-A1 TOPICALLY ADMINISTRABLE COMPOSITIONS CONTAINING 3-BENZOYLPHENYLACETIC ACID DERIVATIVES FOR TREATMENT OF OPHTHALMIC INFLAMMATORY DISORDERS ALCON LABORATORIES, INC. (US) 1995-12-14 WO disclosed
US-5475034-A Adminstering 3-benzoylphenylacetamide derivatives ALCON LABORATORIES, INC. (US) 1995-12-12 US disclosed