Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1569351 | 0.82 | GAA (0.40) | MAPTGAALMNAADORA1ABCB11 | |
| SCHEMBL30692375 | 0.80 | MAPT (0.45) | MAPTGAALMNAADORA1ABCB11 | |
| SCHEMBL1569324 | 0.80 | MAPT (0.45) | MAPTGAALMNAADORA1ABCB11 | |
| SCHEMBL1569323 | 0.79 | MAPT (0.44) | MAPTGAALMNAADORA1ABCB11 | |
| SCHEMBL11793034 | 0.78 | HSD17B10 (0.38) | GAAALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL1569026 | 0.78 | MAPT (0.43) | MAPTGAALMNAADORA1ABCB11 | |
| SCHEMBL11501238 | 0.76 | ALDH1A1 (0.42) | MAPTGAALMNAADORA1ABCB11 | |
| SCHEMBL10584727 | 0.73 | EPHX1 (0.54) | LMNACYP1A2CYP2C19 | |
| SCHEMBL12851447 | 0.72 | MAPT (0.49) | MAPTGAALMNAADORA1ABCB11 | |
| SCHEMBL7529565 | 0.72 | NR4A1 (0.38) | MAPTLMNAADORA1ABCB11PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630909-B2 | Process for the preparation of nepafenac | MYLAN LABORATORIES LTD (IN) | 2017-04-25 | — | — | US | disclosed |
| US-20160214927-A1 | Process for the preparation of nepafenac | MYLAN LABORATORIES LTD, (IN) | 2016-07-28 | — | — | US | disclosed |
| EP-3013790-A1 | PROCESS FOR THE PREPARATION OF NEPAFENAC | Mylan Laboratories Ltd. (IN) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014207769-A1 | PROCESS FOR THE PREPARATION OF NEPAFENAC | MYLAN LABORATORIES LTD (IN) | 2014-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214927-A1 | Process for the preparation of nepafenac | SCN2B, SCN3A, SCN2A | MAPT 1784/4885GAA 1146/4885LMNA 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.