Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.68 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.63 |
| ▸ | OSBP | P22059 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | RORC | P51449 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.59 |
| ▸ | NPC1L1 | Q9UHC9 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
| ▸ | UGCG | Q16739 | 2/20 | 0.53 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1296890 | 0.96 | POLA1 (0.73) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL19460417 | 0.96 | POLA1 (0.73) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL1296888 | 0.96 | POLA1 (0.73) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL4437346 | 0.96 | POLA1 (0.73) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL1296893 | 0.93 | POLA1 (0.75) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL27673628 | 0.92 | POLA1 (0.65) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL4660535 | 0.90 | POLA1 (0.68) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL28207876 | 0.89 | POLA1 (0.69) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL2979168 | 0.89 | POLA1 (0.69) | POLA1CYP46A1OSBPUSP2RORC | |
| SCHEMBL9186858 | 0.89 | POLA1 (0.69) | POLA1CYP46A1OSBPUSP2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189607-A2 | ANTI-TUMOR ACTIVITY OF VITAMIN E, CHOLESTEROL, TAXOL AND BETULINIC ACID DERIVATIVES | Washington State University Research Foundation (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000059492-A2 | ANTI-TUMOR ACTIVITY OF VITAMIN E, CHOLESTEROL, TAXOL AND BETULINIC ACID DERIVATIVES | WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2000-10-12 | — | — | WO | disclosed |