Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 5/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146999 | 1.00 | PIK3R1 (0.40) | PIK3R1PIK3CAPDE5APDE7APDE7B | |
| SCHEMBL6854129 | 0.93 | MAPT (0.41) | PDE7APDE7BALDH1A1MAPTLMNA | |
| SCHEMBL6855972 | 0.93 | MAPT (0.41) | PDE7APDE7BALDH1A1MAPTLMNA | |
| SCHEMBL6854057 | 0.92 | MAPT (0.42) | PDE7APDE7BALDH1A1MAPTLMNA | |
| SCHEMBL6854824 | 0.91 | PIK3R1 (0.44) | PIK3R1PIK3CAALDH1A1MAPTLMNA | |
| SCHEMBL6855837 | 0.91 | PIK3R1 (0.44) | PIK3R1PIK3CAALDH1A1MAPTLMNA | |
| SCHEMBL6854981 | 0.90 | PIK3R1 (0.45) | PIK3R1PIK3CAALDH1A1MAPTLMNA | |
| SCHEMBL7526733 | 0.88 | PIK3R1 (0.42) | PIK3R1PIK3CAMAPTLMNATSHR | |
| SCHEMBL7530001 | 0.87 | PDE7A (0.33) | PIK3R1PIK3CAPDE5APDE7APDE7B | |
| SCHEMBL6850034 | 0.84 | MEN1 (0.42) | PDE7AALDH1A1MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002022112-A9 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING A DISEASE ASSOCIATED WITH AN EXCESS OF IL-12 PRODUCTION | WARNER LAMBERT CO (US) | 2002-06-06 | — | — | WO | disclosed |