Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CLPP | Q16740 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855837 | 0.96 | PIK3R1 (0.44) | PIK3R1PIK3CALMNAMAPTL3MBTL1 | |
| SCHEMBL6854824 | 0.96 | PIK3R1 (0.44) | PIK3R1PIK3CALMNAMAPTL3MBTL1 | |
| SCHEMBL6854981 | 0.96 | PIK3R1 (0.45) | PIK3R1PIK3CALMNAMAPTL3MBTL1 | |
| SCHEMBL6850131 | 0.93 | LMNA (0.43) | LMNAMAPTL3MBTL1SOS1TSHR | |
| SCHEMBL7002152 | 0.92 | L3MBTL1 (0.42) | LMNAMAPTL3MBTL1HRH4CYP3A4 | |
| SCHEMBL6850222 | 0.92 | MAPT (0.44) | LMNAMAPTL3MBTL1SOS1TSHR | |
| SCHEMBL7146999 | 0.88 | PIK3R1 (0.40) | PIK3R1PIK3CALMNAMAPTCNR2 | |
| SCHEMBL7529993 | 0.88 | PIK3R1 (0.40) | PIK3R1PIK3CALMNAMAPTCNR2 | |
| SCHEMBL6850175 | 0.87 | L3MBTL1 (0.44) | LMNAMAPTL3MBTL1TSHRTP53 | |
| SCHEMBL7526734 | 0.87 | PIK3R1 (0.35) | PIK3R1PIK3CALMNAMAPTCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002022112-A9 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING A DISEASE ASSOCIATED WITH AN EXCESS OF IL-12 PRODUCTION | WARNER LAMBERT CO (US) | 2002-06-06 | — | — | WO | disclosed |
| EP-1188438-A1 | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production | WARNER-LAMBERT COMPANY (US) | 2002-03-20 | — | — | EP | disclosed |