Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5196623 | 1.00 | GRM2 (0.44) | GRM2ALDH1A1TSHRLMNAPOLB | |
| SCHEMBL7244999 | 0.92 | GRM2 (0.47) | GRM2ALDH1A1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL5194363 | 0.91 | GRM2 (0.44) | GRM2ALDH1A1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL7623436 | 0.91 | GRM2 (0.44) | GRM2ALDH1A1LMNAPOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7655444 | 0.90 | GRM2 (0.43) | GRM2ALDH1A1LMNAPOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7618249 | 0.84 | GRM2 (0.44) | GRM2ALDH1A1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL7613358 | 0.83 | ALDH1A1 (0.39) | ALDH1A1TSHRLMNAPOLBMEN1 | |
| SCHEMBL7536470 | 0.83 | ALDH1A1 (0.39) | ALDH1A1TSHRLMNAPOLBMEN1 | |
| SCHEMBL176708 | 0.82 | GRM2 (0.41) | GRM2ALDH1A1TSHRLMNAPOLB | |
| SCHEMBL176707 | 0.82 | GRM2 (0.41) | GRM2ALDH1A1TSHRLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495701-B1 | THE PRESENT INVENTION IS DIRECTED TO PROCESSES FOR THE PREPARATION OF A COMPOUND USEFUL FOR TREATING DIABETES, OBESITY, HYPERLIPIDEMIA AND THE LIKE, | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2002-12-17 | — | — | US | disclosed |
| EP-1195371-A1 | PROCESS FOR THE PREPARATION OF TRICYCLIC AMINO ALCOHOL DERIVATIVES | Asahi Kasei Kabushiki Kaisha (JP) | 2002-04-10 | — | — | EP | disclosed |
| EP-1174425-A1 | NOVEL METHOD FOR MANUFACTURING TRICYCLIC AMINO ALCOHOL DERIVATIVES | Asahi Kasei Kabushiki Kaisha (JP) | 2002-01-23 | — | — | EP | disclosed |