Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568331 | 0.93 | HRH3 (0.63) | HRH3SMN1; SMN2HPGDALDH1A1LMNA | |
| SCHEMBL60705 | 0.91 | HRH3 (0.66) | HRH3SMN1; SMN2HPGDALDH1A1LMNA | |
| SCHEMBL27778712 | 0.85 | HRH3 (0.58) | HRH3SMN1; SMN2HPGDALDH1A1LMNA | |
| SCHEMBL3133899 | 0.81 | HRH3 (0.79) | HRH3SMN1; SMN2HPGDALDH1A1LMNA | |
| SCHEMBL447560 | 0.80 | HRH3 (0.71) | HRH3SMN1; SMN2ALDH1A1KDM4ENCF1 | |
| SCHEMBL996532 | 0.80 | HRH3 (0.71) | HRH3SMN1; SMN2ALDH1A1KDM4ENCF1 | |
| SCHEMBL28282914 | 0.78 | HRH3 (0.68) | HRH3SMN1; SMN2ALDH1A1KDM4ENCF1 | |
| SCHEMBL738784 | 0.78 | HRH3 (0.67) | HRH3SMN1; SMN2ALDH1A1KDM4ENCF1 | |
| SCHEMBL7356340 | 0.78 | HRH3 (0.60) | HRH3SMN1; SMN2ALDH1A1KMT2AKDM4E | |
| SCHEMBL15467001 | 0.78 | HRH3 (0.87) | HRH3SMN1; SMN2HPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002543126-A | — | — | 2002-12-17 | — | — | JP | claimed |
| EP-1189609-A4 | CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | claimed |
| EP-1189609-A1 | CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-03-27 | — | — | EP | claimed |
| WO-2000066112-A1 | CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-11-09 | — | — | WO | claimed |