SCHEMBL7568331

SCHEMBL7568331

[c]1ccc(CN2CCOCCOCCOCCOCC2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 4/20 0.63
SMN1; SMN2 Q16637 2/20 0.54
ALDH1A1 P00352 2/20 0.54
LMNA P02545 1/20 0.54
MAPT P10636 1/20 0.54
KCNJ1 P48048 1/20 0.54
CYP2A13 Q16696 4/20 0.49
NCF1 P14598 1/20 0.49
NOS3 P29474 1/20 0.47
NOS1 P29475 1/20 0.47
NOS2 P35228 1/20 0.47
CYP2C9 P11712 1/20 0.47
ALOX15 P16050 1/20 0.47
HSD17B10 Q99714 1/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
HIF1A Q16665 2/20 0.46
EPAS1 Q99814 2/20 0.46
HPGD P15428 1/20 0.46
CXCR4 P61073 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL60705 0.98 HRH3 (0.66) HRH3SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL7530239 0.93 HRH3 (0.58) HRH3SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL27778712 0.91 HRH3 (0.58) HRH3SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL3133899 0.87 HRH3 (0.79) HRH3SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL15467001 0.83 HRH3 (0.87) HRH3SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL8721655 0.83 HRH3 (0.57) HRH3SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL896379 0.80 SIGMAR1 (0.68) HRH3SMN1; SMN2ALDH1A1LMNAMAPT
Water SCHEMBL1702298 0.80 SIGMAR1 (0.68) HRH3SMN1; SMN2ALDH1A1LMNACYP2A13
SCHEMBL948372 0.80 SIGMAR1 (0.68) HRH3SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL18065638 0.80 SIGMAR1 (0.68) HRH3SMN1; SMN2ALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1189609-A4 CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORP (US) 2002-10-30 EP disclosed
EP-1189609-A1 CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORPORATION (US) 2002-03-27 EP disclosed
WO-2000066112-A1 CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORPORATION (US) 2000-11-09 WO disclosed