Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.54 |
| ▸ | CYP2A13 | Q16696 | 4/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60705 | 0.98 | HRH3 (0.66) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL7530239 | 0.93 | HRH3 (0.58) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL27778712 | 0.91 | HRH3 (0.58) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL3133899 | 0.87 | HRH3 (0.79) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL15467001 | 0.83 | HRH3 (0.87) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL8721655 | 0.83 | HRH3 (0.57) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL18065638 | 0.80 | SIGMAR1 (0.68) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL896379 | 0.80 | SIGMAR1 (0.68) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL948372 | 0.80 | SIGMAR1 (0.68) | HRH3SMN1; SMN2ALDH1A1LMNAMAPT | |
| Water SCHEMBL1702298 | 0.80 | SIGMAR1 (0.68) | HRH3SMN1; SMN2ALDH1A1LMNACYP2A13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189609-A4 | CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1189609-A1 | CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000066112-A1 | CXCR-4 RECEPTOR ANTAGONISTS - THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |