Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7529223 | 0.92 | EBP (0.44) | EBPSIGMAR1ESR1NPC1RAB9A | |
| SCHEMBL7528373 | 0.91 | EBP (0.44) | EBPSIGMAR1ESR1NPC1RAB9A | |
| SCHEMBL7531873 | 0.84 | EBP (0.44) | EBPSIGMAR1ESR1NPC1RAB9A | |
| SCHEMBL8625511 | 0.80 | EBP (0.64) | EBPSIGMAR1ESR1NPC1RAB9A | |
| SCHEMBL8609912 | 0.78 | ESR1 (0.51) | EBPSIGMAR1ESR1NPC1RAB9A | |
| SCHEMBL7524279 | 0.77 | EBP (0.41) | EBPSIGMAR1ESR1NPC1RAB9A | |
| SCHEMBL7532740 | 0.75 | EBP (0.39) | EBPSIGMAR1ESR1NPC1RAB9A | |
| SCHEMBL7529402 | 0.74 | EBP (0.41) | EBPSIGMAR1ESR1NPC1RAB9A | |
| SCHEMBL8015672 | 0.71 | EBP (0.88) | EBPSIGMAR1ESR1ESR2 | |
| SCHEMBL9516797 | 0.68 | KDM4E (0.47) | EBPSIGMAR1ESR1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832883-B1 | Tetrahydrobenzo(a)fluorene compounds and methods of use | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |