Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 14/20 | 0.59 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11821605 | 0.83 | ESR1 (0.72) | EBPSIGMAR1ESR1MIFNPC1 | |
| SCHEMBL27320646 | 0.80 | EBP (0.58) | EBPSIGMAR1ESR1MIFALDH1A1 | |
| SCHEMBL7531873 | 0.80 | EBP (0.44) | EBPSIGMAR1ESR1NPC1ALDH1A1 | |
| SCHEMBL7530401 | 0.80 | EBP (0.49) | EBPSIGMAR1ESR1ESR2NPC1 | |
| SCHEMBL7524279 | 0.79 | EBP (0.41) | EBPSIGMAR1ESR1NPC1ALDH1A1 | |
| SCHEMBL2817611 | 0.79 | ESR1 (0.86) | EBPSIGMAR1ESR1MIFESR2 | |
| Nafoxidine SCHEMBL29494604 | 0.78 | EBP (1.00) | EBPSIGMAR1ESR1ESR2 | |
| Nafoxidine SCHEMBL153125 | 0.78 | EBP (1.00) | EBPSIGMAR1ESR1ESR2 | |
| Nafoxidine SCHEMBL10563464 | 0.78 | EBP (1.00) | EBPSIGMAR1ESR1ESR2 | |
| Nafoxidine SCHEMBL115778 | 0.78 | EBP (0.98) | EBPSIGMAR1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719136-A | Combination of progesterone antagonists and antiestrogens with partial agonistic action for hormone substitution therapy for perimenopausal and postmenopausal women | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | claimed |