Sugi Predict

Sugi Predict / Compounds / SCHEMBL7530968

SCHEMBL7530968

SCHEMBL7530968

O=C(NN=Cc1ccc(Br)cc1)c1[nH]c2ccc(F)cc2c1-c1ccccc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 10/20 0.79
▸ LMNA P02545 6/20 0.79
▸ ALDH1A1 P00352 7/20 0.77
▸ KDM4E B2RXH2 6/20 0.77
▸ MEN1 O00255 6/20 0.77
▸ KMT2A Q03164 6/20 0.77
▸ PAX8 Q06710 2/20 0.77
▸ SMN1; SMN2 Q16637 5/20 0.72
▸ HPGD P15428 2/20 0.72
▸ RAB9A P51151 2/20 0.72
▸ POLB P06746 2/20 0.64
▸ TP53 P04637 1/20 0.64
▸ TUBB4A P04350 2/20 0.64
▸ TUBB P07437 2/20 0.64
▸ TUBA3C P0DPH7 2/20 0.64
▸ TUBA1B P68363 2/20 0.64
▸ TUBA4A P68366 2/20 0.64
▸ TUBB4B P68371 2/20 0.64
▸ TUBB3 Q13509 2/20 0.64
▸ TUBB2A Q13885 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7559802 1.00 MAPT (0.79) MAPTLMNAALDH1A1KDM4EMEN1
SCHEMBL7527872 0.94 MAPT (0.86) MAPTLMNAALDH1A1KDM4EMEN1
SCHEMBL7674555 0.94 MAPT (0.86) MAPTLMNAALDH1A1KDM4EMEN1
SCHEMBL7558826 0.94 MAPT (0.72) MAPTLMNAALDH1A1KDM4EMEN1
SCHEMBL7558822 0.94 MAPT (0.72) MAPTLMNAALDH1A1KDM4EMEN1
SCHEMBL7560286 0.93 MAPT (0.77) MAPTLMNAALDH1A1KDM4EMEN1
SCHEMBL7560290 0.93 MAPT (0.77) MAPTLMNAALDH1A1KDM4EMEN1
SCHEMBL7534796 0.92 MAPT (0.94) MAPTLMNAALDH1A1KDM4EMEN1
SCHEMBL7560228 0.92 MAPT (0.94) MAPTLMNAALDH1A1KDM4EMEN1
SCHEMBL7560557 0.90 TUBB4A (0.75) MAPTLMNAALDH1A1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020091148-A1 3-substituted indole antiproliferative angiogenesis inhibitors ABBOTT LABORATORIES 2002-07-11 — — US claimed
WO-2002022576-A2 3-SUBSTITUTED INDOLE CARBOHYDRAZIDES USEFUL AS CELL PROLIFERATION AND ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 2002-03-21 — — WO claimed
US-20020091148-A1 3-substituted indole antiproliferative angiogenesis inhibitors ABBOTT LABORATORIES 2002-07-11 — — US disclosed
WO-2002022576-A2 3-SUBSTITUTED INDOLE CARBOHYDRAZIDES USEFUL AS CELL PROLIFERATION AND ANGIOGENESIS INHIBITORS ABBOTT LABORATORIES (US) 2002-03-21 — — WO disclosed
US-6323228-B1 INHIBITING ANGIOGENESIS IN A MAMMAL IN RECOGNIZED NEED OF SUCH TREATMENT COMPRISING ADMINISTERING TO THE MAMMAL WITH INDOLE SUBSTITUTED WITH HYDRAZIDES ABBOTT LABORATORIES 2001-11-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020091148-A1 3-substituted indole antiproliferative angiogenesis inhibitors MKI67, FLT4, IDO1 MAPT 4828/4885LMNA 4535/4885ALDH1A1 98/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.