Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.46 |
| ▸ | CCND1 | P24385 | 4/20 | 0.46 |
| ▸ | PRKACA | P17612 | 4/20 | 0.46 |
| ▸ | PRKACG | P22612 | 4/20 | 0.46 |
| ▸ | PRKACB | P22694 | 4/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.41 |
| ▸ | QPCT | Q16769 | 5/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526686 | 0.83 | GSK3B (0.44) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7496386 | 0.79 | CDK4 (0.55) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL6424023 | 0.79 | CDK4 (0.71) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL7058746 | 0.77 | CCNE2 (0.71) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL7988627 | 0.77 | CDK2 (0.43) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL668748 | 0.77 | CCNE2 (0.57) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7598668 | 0.76 | CDK2 (0.42) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7599053 | 0.76 | CCNE2 (0.51) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL7497956 | 0.74 | GSK3B (0.57) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7524287 | 0.73 | CDK2 (0.44) | CDK4CCND1CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |