Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 7/20 | 0.71 |
| ▸ | CCND1 | P24385 | 7/20 | 0.71 |
| ▸ | PRKACA | P17612 | 7/20 | 0.71 |
| ▸ | PRKACG | P22612 | 7/20 | 0.71 |
| ▸ | PRKACB | P22694 | 7/20 | 0.71 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.71 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.71 |
| ▸ | CDK2 | P24941 | 5/20 | 0.71 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.59 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | PRKCG | P05129 | 2/20 | 0.53 |
| ▸ | PRKCB | P05771 | 2/20 | 0.53 |
| ▸ | PRKCA | P17252 | 2/20 | 0.53 |
| ▸ | PRKCH | P24723 | 2/20 | 0.53 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.53 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7058746 | 0.92 | CCNE2 (0.71) | CDK4CCND1PRKACAPRKACGPRKACB | |
| Enmd-981693 SCHEMBL29350364 | 0.88 | CCNE2 (0.69) | CDK4CCND1CCNE2CCNE1CDK2 | |
| Enmd-981693 SCHEMBL608128 | 0.88 | CCNE2 (0.69) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL7496386 | 0.88 | CDK4 (0.55) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL668748 | 0.87 | CCNE2 (0.57) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL9087452 | 0.86 | PRKACA (0.66) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL9088178 | 0.85 | PRKACA (0.67) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL9087198 | 0.85 | CDK4 (0.67) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL7599053 | 0.84 | CCNE2 (0.51) | CDK4CCND1PRKACAPRKACGPRKACB | |
| SCHEMBL9088204 | 0.84 | CAMK2D (0.74) | CDK4CCND1PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988863-B2 | Stable complexes of poorly soluble compounds | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | disclosed |
| EP-1242408-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | disclosed |
| EP-1441772-A2 | POLYMER CONJUGATES OF PROTEIN KINASE C INHIBITORS | Nektar Therapeutics Al, Corporation (US) | 2004-08-04 | — | — | EP | disclosed |
| US-20030143185-A1 | Polymer conjugates of protein kinase C inhibitors | SHEARWATER CORPORATION | 2003-07-31 | — | — | US | disclosed |
| EP-1064279-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2003-06-25 | — | — | EP | disclosed |
| WO-2003043632-A2 | USE OF BISINDOLMALEIMIDE AND GEMCITABINE FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-30 | — | — | WO | disclosed |
| WO-2003037384-A2 | POLYMER CONJUGATES OF PROTEIN KINASE C INHIBITORS | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2003-05-08 | — | — | WO | disclosed |
| EP-1242408-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6313143-B1 | USEFUL IN THERAPY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | disclosed |
| WO-2001044234-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-21 | — | — | WO | disclosed |
| EP-1064279-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F.HOFFMANN-LA ROCHE AG (CH) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999047518-A1 | SUBSTITUTED BISINDOLYMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030143185-A1 | Polymer conjugates of protein kinase C inhibitors | PRKCH, PRKCI, PRKCA | CDK4 387/4885CCND1 2154/4885PRKACA 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.