Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533416 | 0.79 | PDE3B (0.37) | PDE3BPDE3AMAOAMAOBALDH1A1 | |
| SCHEMBL5654974 | 0.74 | MIF (0.39) | MAOAMAOB | |
| SCHEMBL5654967 | 0.74 | MIF (0.39) | MAOAMAOB | |
| SCHEMBL5865856 | 0.67 | CSF1R (0.33) | PDE3BPDE3AMAOAMAOBALDH1A1 | |
| SCHEMBL5654140 | 0.66 | MIF (0.39) | PDE3BPDE3AMAOAMAOBALDH1A1 | |
| SCHEMBL5654137 | 0.66 | MIF (0.39) | PDE3BPDE3AMAOAMAOBALDH1A1 | |
| SCHEMBL5865860 | 0.65 | MIF (0.39) | ALDH1A1ALOX15MAPK10HSD17B10 | |
| SCHEMBL5865858 | 0.65 | MIF (0.39) | ALDH1A1ALOX15MAPK10HSD17B10 | |
| SCHEMBL7472789 | 0.64 | CYP2E1 (0.39) | PDE3BPDE3AMAOAMAOB | |
| SCHEMBL5655207 | 0.63 | MIF (0.45) | MAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242416-A1 | SUBSTITUTED ISOXAZOLINES AND THEIR USE AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001040222-A1 | SUBSTITUTED ISOXAZOLINES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2001-06-07 | — | — | WO | disclosed |