Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.80 |
| ▸ | EGFR | P00533 | 2/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 9/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1462064 | 0.92 | MAP2K1 (0.83) | MAP2K1EGFRERBB2KDRMAPK14 | |
| SCHEMBL27888274 | 0.86 | EGFR (0.82) | MAP2K1EGFRERBB2KDR | |
| SCHEMBL14451958 | 0.84 | MAP2K1 (0.67) | MAP2K1EGFRERBB2KDRMAPK14 | |
| SCHEMBL5739048 | 0.83 | MAP2K1 (0.66) | MAP2K1EGFRERBB2KDR | |
| SCHEMBL4046743 | 0.81 | EGFR (1.00) | MAP2K1EGFRERBB2KDR | |
| SCHEMBL4050078 | 0.80 | KDR (0.72) | MAP2K1EGFRERBB2KDRMAPK14 | |
| SCHEMBL7600802 | 0.80 | KDR (0.57) | MAP2K1EGFRERBB2KDRMAPK14 | |
| SCHEMBL5516114 | 0.79 | KDR (0.80) | EGFRKDR | |
| SCHEMBL13045178 | 0.79 | MAP2K1 (0.74) | MAP2K1 | |
| SCHEMBL7530745 | 0.78 | KDR (0.70) | MAP2K1EGFRERBB2KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | claimed |
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | disclosed |
| EP-1183033-A4 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2002-07-17 | — | — | EP | disclosed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | disclosed |
| EP-1183033-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071129-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-30 | — | — | WO | disclosed |