Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053673 | 0.92 | KDR (0.68) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL4044547 | 0.88 | MAP2K1 (0.67) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL4049775 | 0.87 | EGFR (0.58) | KDRMAP2K1MEN1USP2PABPC1 | |
| SCHEMBL14451959 | 0.83 | KDR (0.48) | KDRMAP2K1MEN1PABPC1KMT2A | |
| SCHEMBL5739638 | 0.83 | KDR (0.48) | KDRMAP2K1MEN1PABPC1KMT2A | |
| SCHEMBL7536628 | 0.81 | KDR (0.68) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL5522435 | 0.81 | KDR (0.62) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL4051995 | 0.81 | EGFR (0.58) | KDREGFRERBB2 | |
| SCHEMBL5740293 | 0.80 | MAP2K1 (0.49) | KDRMAP2K1EGFRERBB2MAPK14 | |
| SCHEMBL5516129 | 0.80 | EGFR (0.68) | KDRMAP2K1EGFRERBB2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-A4 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1183033-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071129-A1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-11-30 | — | — | WO | disclosed |