Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.52 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.52 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.52 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29808947 | 0.83 | HDAC1 (0.73) | HDAC1HDAC6ABCC9ABCC8KCNJ11 | |
| SCHEMBL6106476 | 0.83 | HDAC1 (0.73) | HDAC1HDAC6ABCC9ABCC8KCNJ11 | |
| SCHEMBL3415898 | 0.81 | HDAC1 (0.57) | HDAC1HDAC6ABCC9ABCC8KCNJ11 | |
| SCHEMBL14254877 | 0.81 | HTT (0.60) | RAB9AALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL8368410 | 0.81 | PDK1 (0.56) | KDM4ENPSR1ALDH1A1ALOX12SMN1; SMN2 | |
| SCHEMBL7144520 | 0.81 | KDM4E (0.47) | HDAC1HDAC6KDM4ECA1CA2 | |
| SCHEMBL31501240 | 0.80 | CYP17A1 (0.60) | HDAC1HDAC6ABCC9ABCC8KCNJ11 | |
| SCHEMBL478852 | 0.80 | CYP17A1 (0.60) | HDAC1HDAC6ABCC9ABCC8KCNJ11 | |
| SCHEMBL8365483 | 0.79 | KDM4E (0.46) | KDM4ENPSR1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL478495 | 0.79 | HDAC1 (0.54) | HDAC1HDAC6CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755928-B1 | 5-AMINOFLAVONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2002-04-10 | — | — | EP | disclosed |
| EP-0638566-B1 | 5-Aminoflavone derivatives, their preparation and their use as antibacterial, anti-estrogenic and/or antitumor agent | KYOWA HAKKO KOGYO KK (JP) | 1999-01-07 | — | — | EP | disclosed |
| EP-0556720-B1 | 5-Aminoflavone derivatives | KYOWA HAKKO KOGYO KK (JP) | 1997-09-17 | — | — | EP | disclosed |
| EP-0755928-A1 | 5-AMINOFLAVONE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-01-29 | — | — | EP | disclosed |
| US-5539112-A | 5-aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-07-23 | — | — | US | disclosed |
| EP-0638566-A1 | 5-Aminoflavone derivatives, their preparation and their use as antibacterial, anti-estrogenic and/or antitumor agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |
| EP-0556720-A1 | 5-Aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |
| EP-0374789-A1 | 5- Aminoflavone derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-06-27 | — | — | EP | disclosed |