SCHEMBL7532054

SCHEMBL7532054

CC(=O)c1ccccc1-c1ccccc1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BAZ2B Q9UIF8 1/20 0.50
BAZ2A Q9UIF9 1/20 0.50
KDM4E B2RXH2 7/20 0.46
HPGD P15428 5/20 0.46
ALDH1A1 P00352 5/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
THRB P10828 1/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
HMGB1 P09429 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
NAPRT Q6XQN6 1/20 0.46
CA14 Q9ULX7 1/20 0.46
MEN1 O00255 4/20 0.46
KMT2A Q03164 4/20 0.46
MAPT P10636 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL978600 0.89 KDM4C (0.50) KDM4EALDH1A1SMN1; SMN2MEN1KMT2A
SCHEMBL11775109 0.83 CHEK1 (0.46) BAZ2BBAZ2AKDM4EHPGDALDH1A1
SCHEMBL30293783 0.81 KDM4E (0.61) KDM4EHPGDALDH1A1SMN1; SMN2THRB
SCHEMBL40865 0.81 KDM4E (0.61) KDM4EHPGDALDH1A1SMN1; SMN2THRB
SCHEMBL29876454 0.80 ALDH1A1 (0.67) KDM4EHPGDALDH1A1SMN1; SMN2CA12
SCHEMBL1919550 0.80 ALDH1A1 (0.67) KDM4EHPGDALDH1A1SMN1; SMN2CA12
SCHEMBL9223049 0.80 CYP3A4 (0.60) KDM4EHPGDALDH1A1SMN1; SMN2CA12
SCHEMBL11598403 0.79 KDM4E (0.58) KDM4EHPGDALDH1A1SMN1; SMN2THRB
SCHEMBL10781613 0.79 KDM4E (0.58) KDM4EHPGDALDH1A1SMN1; SMN2THRB
SCHEMBL11410201 0.79 KDM4E (0.58) KDM4EHPGDALDH1A1SMN1; SMN2THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0615448-B1 SEX STEROID ACTIVITY INHIBITORS ENDORECH INC (CA) 2002-05-02 EP disclosed
US-5840735-A ESTROGEN ENDORECHERCHE INC. (CA) 1998-11-24 US disclosed
US-5686465-A PROVIDE ANTIESTROGENIC EFFECTS; USEFUL IN TREATMENT OF BREAST CANCER ENDORECHERCHE INC. (CA) 1997-11-11 US disclosed
US-5395842-A Inhibitors of sex steroids ENDORECHERCHE INC. (CA) 1995-03-07 US disclosed
EP-0615448-A1 SEX STEROID ACTIVITY INHIBITORS ENDORECHERCHE INC. (CA) 1994-09-21 EP disclosed
WO-1993010741-A2 SEX STEROID ACTIVITY INHIBITORS ENDORECHERCHE INC. (CA) 1993-06-10 WO disclosed
EP-0190815-A2 Process for producing aromatic diols CELANESE CORPORATION (US) 1986-08-13 EP disclosed