Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.47 |
| ▸ | UGCG | Q16739 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7531616 | 1.00 | CHRNA7 (0.53) | CHRNA7HTR2CDRD3HTR1AOPRM1 | |
| SCHEMBL7534927 | 1.00 | CHRNA7 (0.53) | CHRNA7HTR2CDRD3HTR1AOPRM1 | |
| SCHEMBL7525138 | 1.00 | CHRNA7 (0.53) | CHRNA7HTR2CDRD3HTR1AOPRM1 | |
| SCHEMBL7682663 | 0.90 | CHRNA7 (0.56) | CHRNA7HTR2CDRD3HTR1AOPRM1 | |
| SCHEMBL7684687 | 0.90 | CHRNA7 (0.56) | CHRNA7HTR2CDRD3HTR1AOPRM1 | |
| SCHEMBL7682662 | 0.90 | CHRNA7 (0.56) | CHRNA7HTR2CDRD3HTR1AOPRM1 | |
| SCHEMBL7684931 | 0.84 | CHRNA7 (0.60) | CHRNA7HTR2CDRD3HTR1AOPRM1 | |
| SCHEMBL7686376 | 0.84 | CHRNA7 (0.60) | CHRNA7HTR2CDRD3HTR1AOPRM1 | |
| SCHEMBL7684935 | 0.84 | CHRNA7 (0.60) | CHRNA7HTR2CDRD3HTR1AOPRM1 | |
| SCHEMBL8092402 | 0.83 | HTR2C (0.54) | CHRNA7HTR2CDRD3HTR1AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192141-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS | AstraZeneca UK Limited (GB) | 2002-04-03 | — | — | EP | claimed |
| WO-2000078736-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS | ASTRAZENECA UK LIMITED (GB) | 2000-12-28 | — | — | WO | claimed |