Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682663 | 1.00 | CHRNA7 (0.56) | CHRNA7HTR2COPRM1OPRK1OPRL1 | |
| SCHEMBL7682662 | 1.00 | CHRNA7 (0.56) | CHRNA7HTR2COPRM1OPRK1OPRL1 | |
| SCHEMBL7532611 | 0.90 | CHRNA7 (0.53) | CHRNA7HTR2COPRM1OPRK1OPRL1 | |
| SCHEMBL7531616 | 0.90 | CHRNA7 (0.53) | CHRNA7HTR2COPRM1OPRK1OPRL1 | |
| SCHEMBL7534927 | 0.90 | CHRNA7 (0.53) | CHRNA7HTR2COPRM1OPRK1OPRL1 | |
| SCHEMBL7525138 | 0.90 | CHRNA7 (0.53) | CHRNA7HTR2COPRM1OPRK1OPRL1 | |
| SCHEMBL7678354 | 0.88 | HTR2C (0.54) | CHRNA7HTR2COPRM1OPRK1OPRL1 | |
| SCHEMBL8092402 | 0.88 | HTR2C (0.54) | CHRNA7HTR2COPRM1OPRK1OPRL1 | |
| SCHEMBL8096401 | 0.88 | HTR2C (0.54) | CHRNA7HTR2COPRM1OPRK1OPRL1 | |
| SCHEMBL7684931 | 0.86 | CHRNA7 (0.60) | CHRNA7HTR2COPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417183-B1 | DRUGS RELATES TO 1,4-DIAZACYCLOHEPTANES, TO PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND TO THEIR USE IN METHODS OF THERAPEUTIC TREATMENT OF NERVOUS SYSTEM DISORDERS | ASTRAZENELA UK LIMITED (GB) | 2002-07-09 | — | — | US | claimed |
| EP-1060169-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES | AstraZeneca AB (SE) | 2000-12-20 | — | — | EP | claimed |
| WO-1999032461-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-07-01 | — | — | WO | claimed |