Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 5/20 | 0.45 |
| ▸ | RARA | P10276 | 4/20 | 0.45 |
| ▸ | RARG | P13631 | 2/20 | 0.45 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.44 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.44 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.44 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | PTGFR | P43088 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2407352 | 0.87 | EPHX2 (0.44) | EPHX2NR1H4RARBRARARARG | |
| SCHEMBL22855238 | 0.83 | KDM4E (0.43) | ABCC9ABCC8KCNJ11KCNJ8MEN1 | |
| SCHEMBL18309782 | 0.83 | GAA (0.50) | EPHX2NR1H4ABCC9ABCC8KCNJ11 | |
| SCHEMBL24965982 | 0.83 | EPHX2 (0.41) | EPHX2NR1H4RARBRARARARG | |
| SCHEMBL22504471 | 0.81 | KMT2A (0.53) | SLC22A12MEN1USP2ALDH1A1HPGD | |
| SCHEMBL2432970 | 0.80 | RARB (0.48) | EPHX2NR1H4RARBRARARARG | |
| SCHEMBL13610858 | 0.79 | SMN1; SMN2 (0.52) | NR1H4HTTMEN1ALDH1A1HPGD | |
| SCHEMBL8829073 | 0.79 | RARB (0.46) | EPHX2NR1H4RARBRARARARG | |
| SCHEMBL18832261 | 0.78 | EPHX2 (0.41) | EPHX2NR1H4RARBRARARARG | |
| SCHEMBL18856971 | 0.78 | EPHX2 (0.41) | EPHX2NR1H4RARBRARARARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996563-B1 | HETEROBICYCLIC SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES | HOFFMANN LA ROCHE (CH) | 2012-03-21 | — | — | EP | disclosed |