Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8114579 | 0.95 | MEN1 (0.60) | MEN1KMT2AMAPK10ALDH1A1MAPT | |
| SCHEMBL8112067 | 0.89 | MAPT (0.49) | MEN1KMT2AMAPK10ALDH1A1MAPT | |
| SCHEMBL27553167 | 0.86 | MEN1 (0.46) | MEN1KMT2AMAPK10ALDH1A1MAPT | |
| SCHEMBL8119108 | 0.84 | MAPT (0.47) | MEN1KMT2AMAPK10ALDH1A1MAPT | |
| SCHEMBL27486435 | 0.77 | MAPT (0.77) | MEN1KMT2AMAPK10ALDH1A1MAPT | |
| SCHEMBL8117765 | 0.74 | ALK (0.43) | ALDH1A1GAAHTTKDM4E | |
| SCHEMBL27573252 | 0.74 | NPSR1 (0.40) | MEN1KMT2AALDH1A1MAPTNPSR1 | |
| SCHEMBL31457176 | 0.71 | ADORA2A (0.67) | MEN1KMT2AMAPK10ALDH1A1MAPT | |
| SCHEMBL6180465 | 0.70 | HTR1A (0.59) | — | |
| SCHEMBL8103974 | 0.69 | ALK (0.42) | ALDH1A1GAAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |
| EP-1047691-A1 | QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999031086-A1 | QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-24 | — | — | WO | disclosed |