Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 19/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535194 | 0.89 | TACR1 (0.46) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL4915733 | 0.84 | TACR1 (0.52) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL6403513 | 0.84 | TACR1 (0.51) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL7533671 | 0.79 | TACR1 (0.64) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL4907938 | 0.78 | TACR1 (0.65) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL6401334 | 0.78 | TACR1 (0.65) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL6402148 | 0.78 | TACR1 (0.65) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL6406702 | 0.77 | TACR1 (0.53) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL4917686 | 0.77 | TACR1 (0.66) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL4919798 | 0.77 | TACR1 (0.66) | TACR1CYP2D6KCNH2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032571-B1 | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLIC ETHER COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER (US) | 2002-06-12 | — | — | EP | claimed |