Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966236 | 0.91 | ESR1 (0.53) | ESR1ESR2HTR2AHRH1CYP19A1 | |
| SCHEMBL7527912 | 0.90 | ESR1 (0.46) | ESR1ESR2CYP19A1NPC1MEN1 | |
| SCHEMBL8966091 | 0.90 | ESR1 (0.57) | ESR1ESR2HTR2AHRH1CYP19A1 | |
| SCHEMBL7535540 | 0.89 | ESR1 (0.47) | ESR1ESR2HTR2AHRH1CYP19A1 | |
| SCHEMBL7527845 | 0.86 | ESR1 (0.45) | ESR1ESR2HTR2AHRH1CYP19A1 | |
| SCHEMBL7523887 | 0.85 | ESR1 (0.44) | ESR1ESR2HTR2AHRH1CYP19A1 | |
| SCHEMBL7531367 | 0.85 | ESR1 (0.44) | ESR1ESR2HTR2AHRH1CYP19A1 | |
| SCHEMBL7530105 | 0.84 | PTPN1 (0.41) | ESR1ESR2CYP19A1PTPN1NPC1 | |
| SCHEMBL7533104 | 0.84 | ESR1 (0.45) | ESR1ESR2HTR2AHRH1CYP19A1 | |
| SCHEMBL7528465 | 0.83 | ESR1 (0.52) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10130211-A | — | — | None | — | — | JP | disclosed |
| EP-0832881-B1 | Benzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| JP-H10130211-A | BENZOFLUORENE COMPOUND, INTERMEDIATE, COMPOSITION, AND METHOD | ELI LILLY & CO | 1998-05-19 | — | — | JP | disclosed |
| EP-0832881-A2 | Benzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |