Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535540 | 0.91 | ESR1 (0.47) | ESR1ESR2PTPN1TUBB4ATUBB | |
| SCHEMBL7527845 | 0.88 | ESR1 (0.45) | ESR1ESR2PTPN1TUBB4ATUBB | |
| SCHEMBL7523887 | 0.87 | ESR1 (0.44) | ESR1ESR2PTPN1TUBB4ATUBB | |
| SCHEMBL7526863 | 0.87 | ESR1 (0.38) | ESR1ESR2CYP19A1KDM4EALDH1A1 | |
| SCHEMBL8966236 | 0.86 | ESR1 (0.53) | ESR1ESR2PTPN1TUBB4ATUBB | |
| SCHEMBL7533104 | 0.85 | ESR1 (0.45) | ESR1ESR2PTPN1TUBB4ATUBB | |
| SCHEMBL7534293 | 0.85 | ESR1 (0.47) | ESR1ESR2PTPN1TUBB4ATUBB | |
| SCHEMBL7527079 | 0.83 | ESR1 (0.42) | ESR1ESR2DPP4KDM4EALDH1A1 | |
| SCHEMBL8966091 | 0.81 | ESR1 (0.57) | ESR1ESR2PTPN1TUBB4ATUBB | |
| SCHEMBL7530105 | 0.80 | PTPN1 (0.41) | ESR1ESR2PTPN1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832881-B1 | Benzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0832881-A2 | Benzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |