Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30640434 | 1.00 | MDM4 (0.49) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL25355516 | 0.91 | MDM2 (0.48) | MDM4TP53MDM2CASP3ACE | |
| SCHEMBL31688959 | 0.91 | MDM2 (0.48) | MDM4TP53MDM2CASP3ACE | |
| SCHEMBL25355519 | 0.91 | MDM2 (0.48) | MDM4TP53MDM2CASP3ACE | |
| SCHEMBL29203319 | 0.91 | PTPN1 (0.51) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL29203318 | 0.91 | PTPN1 (0.51) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL31369702 | 0.91 | MDM2 (0.49) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL25179543 | 0.90 | FPR2 (0.53) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL25179542 | 0.90 | FPR2 (0.53) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL30802553 | 0.90 | FPR2 (0.53) | MDM4TP53MDM2CASP3SLC17A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002016314-A1 | SUBSTITUTED POLYAMINE COMPOUNDS | H. LUNDBECK A/S (DK) | 2002-02-28 | — | — | WO | disclosed |