Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.46 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.46 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18263759 | 0.85 | EPHX2 (0.46) | NAMPTTPSAB1TPSD1TPSG1EPHX2 | |
| SCHEMBL10739048 | 0.84 | TDP1 (0.65) | TDP1HTTNAMPTMEN1KMT2A | |
| SCHEMBL28273729 | 0.84 | TDP1 (0.65) | TDP1HTTNAMPTMEN1KMT2A | |
| SCHEMBL28165171 | 0.84 | TDP1 (0.65) | TDP1HTTNAMPTMEN1KMT2A | |
| SCHEMBL4285086 | 0.84 | TDP1 (0.65) | TDP1HTTNAMPTMEN1KMT2A | |
| SCHEMBL24176160 | 0.84 | TDP1 (0.65) | TDP1HTTNAMPTMEN1KMT2A | |
| SCHEMBL10739485 | 0.84 | TDP1 (0.65) | TDP1HTTNAMPTMEN1KMT2A | |
| SCHEMBL390208 | 0.83 | EPHX2 (0.46) | HTTTPSAB1TPSD1TPSG1EPHX2 | |
| SCHEMBL20542744 | 0.82 | NAAA (0.57) | EPHX2MEN1KMT2AGAAKEAP1 | |
| SCHEMBL12846763 | 0.82 | KMT2A (0.66) | HTTEPHX2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173424-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066566-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |