Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SAT1 | P21673 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23568387 | 0.98 | KDM4E (0.47) | KDM4ERECQLMEN1KMT2ACYP2C19 | |
| SCHEMBL22856505 | 0.98 | KDM4E (0.47) | KDM4ERECQLMEN1KMT2ACYP2C19 | |
| SCHEMBL15025288 | 0.98 | KDM4E (0.47) | KDM4ERECQLMEN1KMT2ACYP2C19 | |
| SCHEMBL10350619 | 0.98 | KDM4E (0.47) | KDM4ERECQLMEN1KMT2ACYP2C19 | |
| SCHEMBL15114177 | 0.98 | KDM4E (0.47) | KDM4ERECQLMEN1KMT2ACYP2C19 | |
| SCHEMBL19956079 | 0.88 | KDM4E (0.52) | KDM4ERECQLMEN1KMT2ACYP2C19 | |
| SCHEMBL3797316 | 0.87 | CYP2C19 (0.45) | KDM4ERECQLMEN1KMT2ACYP2C19 | |
| SCHEMBL3570047 | 0.85 | KDM4E (0.52) | KDM4ERECQLMEN1KMT2ATSHR | |
| SCHEMBL6686436 | 0.85 | KDM4E (0.52) | KDM4ERECQLMEN1KMT2ATSHR | |
| SCHEMBL1507545 | 0.85 | KDM4E (0.52) | KDM4ERECQLMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200395-A1 | UREA DERIVATIVES AS INHIBITORS OF CCR-3 RECEPTOR | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009088-A1 | UREA DERIVATIVES AS INHIBITORS OF CCR-3 RECEPTOR | KIRIN BEER KABUSHIKI KAISHA (JP) | 2001-02-08 | — | — | WO | disclosed |