Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 10/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13791670 | 0.98 | NR1I2 (0.66) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL13791115 | 0.97 | KCNH2 (0.69) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL13792497 | 0.95 | NR1I2 (0.61) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL13792409 | 0.92 | KCNH2 (0.65) | NR1I2KCNH2CYP3A4SCN5ASCN9A | |
| SCHEMBL14070222 | 0.92 | NR1I2 (0.59) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL13791972 | 0.91 | KCNH2 (0.57) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL13791943 | 0.91 | NR1I2 (0.67) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL50562 | 0.91 | KCNH2 (0.68) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL4828051 | 0.91 | NR1I2 (0.63) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 | |
| SCHEMBL13940550 | 0.89 | NR1I2 (0.66) | NR1I2KCNH2CYP3A4SCN5ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099804-B1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2017-03-22 | — | — | EP | disclosed |
| US-8138171-B2 | Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138171-B2 | Dioxolane and dioxolanone fused indolobenzadiazepine HCV NS5B inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-20 | — | — | US | disclosed |
| US-20110020277-A1 | Dioxolane and Dioxolanone Fused Indolobenzadiazepine HCV NS5B Inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-01-27 | — | — | US | disclosed |
| US-20110020277-A1 | Dioxolane and Dioxolanone Fused Indolobenzadiazepine HCV NS5B Inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-01-27 | — | — | US | disclosed |
| US-7541351-B2 | Compounds for the treatment of hepatitis C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-02 | — | — | US | disclosed |
| US-7541351-B2 | Compounds for the treatment of hepatitis C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-02 | — | — | US | disclosed |
| US-20080171015-A1 | Compounds for the Treatment of Hepatitis C | BRISTOL-MYERS SQUIBB COMPANY | 2008-07-17 | — | — | US | disclosed |
| US-20080171015-A1 | Compounds for the Treatment of Hepatitis C | BRISTOL-MYERS SQUIBB COMPANY | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110020277-A1 | Dioxolane and Dioxolanone Fused Indolobenzadiazepine HCV NS5B Inhibitors | SQLE, DHX15, FDFT1 | NR1I2 194/4885KCNH2 1097/4885CYP3A4 257/4885 |
| US-20080171015-A1 | Compounds for the Treatment of Hepatitis C | HAVCR2, HCCS, SLC10A1 | NR1I2 189/4885KCNH2 3808/4885CYP3A4 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.