DHX15 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Molibresib (SCHEMBL1872390)	1.00	1/20
Molibresib (SCHEMBL12671490)	1.00	1/20
Molibresib (SCHEMBL12966358)	1.00	1/20
SCHEMBL9998851	0.91	1/20
SCHEMBL14756282	0.88	1/20
SCHEMBL15980874	0.88	1/20
SCHEMBL12966165	0.87	1/20
SCHEMBL14756215	0.87	1/20
SCHEMBL14756339	0.87	1/20
SCHEMBL15980861	0.87	1/20
SCHEMBL9998825	0.86	1/20
SCHEMBL15980803	0.86	1/20
SCHEMBL1874116	0.85	1/20
SCHEMBL12671221	0.85	1/20
SCHEMBL14756021	0.85	1/20
SCHEMBL14756240	0.85	1/20
SCHEMBL14756287	0.85	1/20
SCHEMBL14756335	0.85	1/20
SCHEMBL14756409	0.85	1/20
SCHEMBL15969460	0.85	1/20

Clinical trials — most relevant to DHX15 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Reverse Transcriptase Inhibitors in AGS	PHASE2	COMPLETED
Pharmacogenetics of Disulfiram for Cocaine	PHASE2	COMPLETED
Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia	PHASE1/PHASE2	COMPLETED
Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema	PHASE2	COMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants	nan	RECRUITING
Better Delineation of DDX3X Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing	nan	RECRUITING
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients	nan	COMPLETED
Identification of the Genetic Causes of Rare Diseases With Negative Exome Findings	nan	UNKNOWN
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
DDX3X Syndrome -The Seaver Autism Center for Research and Treatment is Characterizing DDX3X-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.	nan	COMPLETED
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia	nan	RECRUITING
International PPB/DICER1 Registry	nan	RECRUITING
Shwachman Diamond Syndrome Registry and Study	nan	RECRUITING
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles	nan	ACTIVE_NOT_RECRUITING
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
Diagnosis and Phenotype Characterisation Using Genomics in Patients With Inherited Bone Marrow Failure (IBMDx Study)	nan	RECRUITING
Genetic Investigation of Cancer Predisposition	nan	NOT_YET_RECRUITING
Genetics of Primary Ciliary Dyskinesia	nan	COMPLETED
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Diagnostic Research in Patients With Rare Diseases - Solving the Unsolved Rare Diseases	nan	UNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Interest of High-throughput Sequencing of RNAs for the Diagnosis of Heterogeneous Genetic Diseases	nan	UNKNOWN
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples	nan	COMPLETED
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a DHX15 binder may also engage these)

Protein	Name	Similarity
Q5RAZ4	—	1.000	Q5RAZ4 →
O35286	—	1.000	O35286 →
Q9BKQ8	—	1.000	Q9BKQ8 →
Q20875	—	0.999	Q20875 →
B4NBB0	—	0.999	B4NBB0 →
B0XDC4	—	0.999	B0XDC4 →
Q5XI69	—	0.999	Q5XI69 →
O22899	—	0.999	O22899 →
Q9LZQ9	—	0.999	Q9LZQ9 →
Q6PE54	—	0.997	Q6PE54 →
Q7K3M5	—	0.997	Q7K3M5 →
Q03319	—	0.997	Q03319 →
D4A2Z8	—	0.997	D4A2Z8 →
Q54NJ4	—	0.997	Q54NJ4 →
O42945	—	0.997	O42945 →
B3M383	—	0.996	B3M383 →
Q80VY9	—	0.996	Q80VY9 →
Q5RBD4	—	0.996	Q5RBD4 →
DHX35	Probable ATP-dependent RNA helicase DHX35	0.996	landscape →
Q9H6R0	—	0.995	Q9H6R0 →
B4LX81	—	0.995	B4LX81 →
F4ILR7	—	0.995	F4ILR7 →
Q5R864	—	0.995	Q5R864 →
O17438	—	0.995	O17438 →
Q05B79	—	0.994	Q05B79 →
O45244	—	0.994	O45244 →
B4GEU5	—	0.994	B4GEU5 →
Q22307	—	0.994	Q22307 →
Q14562	—	0.994	Q14562 →
Q09530	—	0.994	Q09530 →