Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 7/20 | 0.34 |
| ▸ | RAB9A | P51151 | 7/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164587 | 0.82 | NPSR1 (0.35) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6164591 | 0.82 | NPSR1 (0.35) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6163715 | 0.78 | NPSR1 (0.35) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6163719 | 0.78 | NPSR1 (0.35) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6183768 | 0.70 | ALDH1A1 (0.38) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6164948 | 0.69 | MAPT (0.45) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6164128 | 0.66 | MEN1 (0.39) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6183323 | 0.66 | ALDH1A1 (0.37) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6163676 | 0.65 | ALDH1A1 (0.39) | MAPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6166651 | 0.64 | SMN1; SMN2 (0.38) | MAPK1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |